| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $800 | In-stock |
| 25mg | $1650 | In-stock |
| 50mg | $2550 | In-stock |
| 100mg | $3800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-119372 |
| M.Wt: | 446.50 |
| Formula: | C26H26N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM. TDP1 Inhibitor-1 shows cytotoxicity against multiple cancer cells. TDP1 Inhibitor-1 can be used for the research of cancer, such as breast cancer[1].
IC50 & Target:IC50: 7 μM (Tyrosyl-DNA Phosphodiesterase 1)[1]
In Vitro:TDP1 Inhibitor-1 (Compound 41a) (100 μM) exhibits TDP1 inhibition with the percentage inhibition of 92%[1].
TDP1 Inhibitor-1 shows cytotoxicity against CCRF-CEM, DU145, A549, and Huh7 cells with IC50 values of 2.63, 4.29, 1.53 and 2.78 μM[1].
TDP1 Inhibitor-1 (1.25-5 μM, 96 h) increases the cytotoxicity of Camptothecin (HY-16560) against MCF-7 cells[1].
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