TDP1 Inhibitor-1


CAS No. : 2248702-80-7

2248702-80-7
Price and Availability of CAS No. : 2248702-80-7
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5mg $450 In-stock
10mg $800 In-stock
25mg $1650 In-stock
50mg $2550 In-stock
100mg $3800 In-stock
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Cat. No. : HY-119372
M.Wt: 446.50
Formula: C26H26N2O5
Purity: >98 %
Solubility: DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 2248702-80-7 :

TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM. TDP1 Inhibitor-1 shows cytotoxicity against multiple cancer cells. TDP1 Inhibitor-1 can be used for the research of cancer, such as breast cancer[1]. IC50 & Target:IC50: 7 μM (Tyrosyl-DNA Phosphodiesterase 1)[1] In Vitro:TDP1 Inhibitor-1 (Compound 41a) (100 μM) exhibits TDP1 inhibition with the percentage inhibition of 92%[1].
TDP1 Inhibitor-1 shows cytotoxicity against CCRF-CEM, DU145, A549, and Huh7 cells with IC50 values of 2.63, 4.29, 1.53 and 2.78 μM[1].
TDP1 Inhibitor-1 (1.25-5 μM, 96 h) increases the cytotoxicity of Camptothecin (HY-16560) against MCF-7 cells[1].

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