CHMFL-ABL-121
CAS No. : 2270879-07-5
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| Cat. No. : | HY-119370 |
| M.Wt: | 580.67 |
| Formula: | C30H31F3N6OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1].
IC50 & Target: IC50: 2 nM (ABL wt kinase) , 0.2 nM (Mutant T315I kinase)[1]
In Vitro: CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC50<10 nM),
MEG-01 (EC50<10 nM) and KU812 (EC50<30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL and ErK[1].
CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase[1].
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