PDE12-IN-1
CAS No. : 2259620-80-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $582 | In-stock |
| 5mg | $1280 | In-stock |
| 10mg | $1800 | In-stock |
| 25mg | $2850 | In-stock |
| 50mg | $3850 | In-stock |
| 100mg | $5400 | In-stock |
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| Cat. No. : | HY-117318 |
| M.Wt: | 616.48 |
| Formula: | C31H27BrFN5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 90 mg/mL (ultrasonic) |
PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 increases 2′,5′-linked adenylate polymers (2-5A) levels, and the pEC50 value is 7.7. PDE12-IN-1 shows antiviral activity[1]. In Vitro: PDE12-IN-1 inhibits the EMCV-induced cytopathic effect in HeLa Ohio cells with a pIC50 of 6.7. PDE12-IN-1 inhibits HeLa Ohio cell proliferation in the absence of EMCV infection with a pIC50 of 5.7. PDE12-IN-1 inhibits the proliferation of both HeLa and HeLaΔPDE12 cells with a pIC50 of 5.7. PDE12-IN-1 inhibits HRV infection with a pIC50 of 6.9[1].
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