GSK 690 (Hydrochloride)
CAS No. : 2436760-79-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $143 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $483 | In-stock |
| 50mg | $764 | In-stock |
| 100mg | $1185 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117226A |
| M.Wt: | 405.92 |
| Formula: | C24H24ClN3O |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.
IC50 & Target:IC50: 37 nM (LSD1), Kd: 8 nM (LSD1)[1].
In Vitro: GSK690 (1-10 μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells)[2].
GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells[2].
GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells[2].
The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest [2].
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