CB-6644
CAS No. : 2316817-88-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $560 | In-stock |
| 10mg | $717 | In-stock |
| 25mg | $1005 | In-stock |
| 50mg | $1307 | In-stock |
| 100mg | $1700 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114429 |
| M.Wt: | 573.06 |
| Formula: | C29H34ClFN4O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM[1].
In Vitro:CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells[1].
CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (including HCT116, NCI-1975, and HT29 cells) with an EC50 range of 41 to 785 nM[1].
In Vivo:CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models[1].
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