TD-428
CAS No. : 2334525-50-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $590 | In-stock |
| 10mg | $950 | In-stock |
| 25mg | $1900 | In-stock |
| 50mg | $3050 | In-stock |
| 100mg | $4880 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114407 |
| M.Wt: | 879.38 |
| Formula: | C43H43ClN10O7S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TD-428 is a PROTAC connected by ligands for Cereblon and BRD4. TD-428 is a highly specific BRD4 degrader with a DC50 of 0.32 nM[1]. TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation[1].
In Vitro:TD-428, which comprises TD-106 linked to a BET inhibitor, JQ1 efficiently induce BET protein degradation in the prostate cancer cell line 22Rv1[1].
TD-428 (0.01-10,000 nM; 72 hours) inhibits the proliferation of 22RV1 cells with a CC50 of 20.1 nM[1].
TD-428 (1 nM-10 μM; 12 hours) induces the degradation of BRD4, IKZF1, and IKZF3 proteins[1].
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- HY-114407
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