AcLysValCit-PABC-DMAE-SW-163D
CAS No. : 2411007-69-5
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| Cat. No. : | HY-114325 |
| M.Wt: | 1817.05 |
| Formula: | C85H113N19O22S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker[1]. IC50 & Target: Drug-Linker Conjugates for ADC[1] In Vitro: SW-163D is a cyclodepsipeptide antibiotic that is isolated from Streptomyces sp. SW-163D also exhibits antitumour activity. PF06888667 is a potent, stable, and efficacious ADC that consists of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline-p-aminobenzyl alcohol-N,N-dimethylethylenediamine (AcLysValCitPABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase[1].
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