PROTAC PARP1 degrader
CAS No. : 2369022-68-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $1040 | In-stock |
| 5mg | $2590 | In-stock |
| 10mg | $4300 | In-stock |
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| Cat. No. : | HY-114324 |
| M.Wt: | 1145.09 |
| Formula: | C58H63Cl2N11O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. PROTAC PARP1 degrader induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader consists of E3 ubiquitinase ligand MDM2 ligand (HY-128836), blue part; target protein ligand PAPR1 ligand (HY-171543), pink part; PROTAC linker N3-PEG4-C2-NH2 (HY-128834), black part[1][2].
IC50 & Target:IC50: 6.12 μM (MDA-MB-231 cell)[1]
In Vitro:PROTAC PARP1 degrader (compound 56) inhibited MDA-MB-231 with an IC50 of 8.45 μM[1].
PROTAC PARP1 degrader (compound 3) (10 μM; 24 h) and significantly induced PARP-1 cleavage and apoptotic responses[2].
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