VZ185
CAS No. : 2306193-61-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $166 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $950 | In-stock |
| 50mg | $1560 | In-stock |
| 100mg | $2600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114322 |
| M.Wt: | 995.21 |
| Formula: | C53H67FN8O8S |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively[1]. IC50 & Target:DC50: 4.5 nM (BRD7), 1.8 nM (BRD9)[1] In Vitro: Degradation analysis in a panel of other human cancer cell lines (EOL-1, A-204) confirms the potency of VZ185 (DC50 between 2 and 8 nM for BRD9). In vitro PK data further showed high stabilities of VZ185 in both plasma and microsomes from both human and mouse species, as well as high aqueous kinetic solubility (up to ~100 μM)[1].
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- HY-114322
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