MRK-740
CAS No. : 2387510-80-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1150 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114209 |
| M.Wt: | 464.56 |
| Formula: | C25H32N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 40 mg/mL (ultrasonic;warming) |
MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50 = 0.8 µM)[1]. IC50 & Target: IC50: 80 nM (PRDM9)[1] In Vitro: After 24 h of treatment, MRK-740 (3 µM) does not affect HEK293T cell growth at the IC90, but some toxicity is observed at 10 µM. MRK-740 is an equipotent inhibitor of H3K4 methylation in MCF7 cells. In cells, MRK-740 specifically and directly inhibits H3K4 methylation at endogenous PRDM9 target loci[1].
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