PROTAC CDK9 degrader-2
CAS No. : 2435721-30-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $395 | In-stock |
| 5mg | $990 | In-stock |
| 10mg | $1585 | In-stock |
| 25mg | $2950 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-112811 |
| M.Wt: | 748.74 |
| Formula: | C39H36N6O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PROTAC CDK9 degrader-2 (compound 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin (CDK ligand) binds ubiquitin E3 ligase Cereblon (CRBN) via a linker to form PROTAC[1].
IC50 & Target:IC50: 17 μM (CDK9, MCF-7 cells)[1]
In Vitro: PROTAC CDK9 degrader-2 (IC50 = 17 μM, 72 h) inhibits proliferation of MCF-7 cells, and induces apoptosis, and is much less active against the CDK9 low-expressed L02 cells (IC50 > 100 μM)[1].
PROTAC CDK9 degrader-2 (1-30 μM, 24 h) selectively degrades CDK9 and Mcl-1 in a dose dependent manner in MCF-7 cells[1].
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- PROTAC CDK9 degrader-2
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- HY-112811
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