SGC-iMLLT
CAS No. : 2255338-25-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112804 |
| M.Wt: | 388.47 |
| Formula: | C22H24N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with Kds of 0.129 and 0.077 μM, respectively[1].
IC50 & Target: IC50: 0.26 μM (MLLT1 YD)[1]
Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)[1]
In Vivo: SGC-iMLLT shows moderate metabolic resistance with t1/2 of 53 min and 48 % remaining after 60 min, and the primary process for metabolism is N demethylation[1].
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- SGC-iMLLT
- Cat. No.:
- HY-112804
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