Carboxy pyridostatin (trifluoroacetate salt)
CAS No. : 2444713-88-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $580 | In-stock |
| 10mg | $980 | In-stock |
| 25mg | $1900 | In-stock |
| 50mg | $3000 | In-stock |
| 100mg | $4500 | In-stock |
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| Cat. No. : | HY-112680A |
| M.Wt: | 820.73 |
| Formula: | C37H35F3N10O9 |
| Purity: | >98 % |
| Solubility: | H2O : 60 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation[1][2][3].
In Vitro:Carboxy pyridostatin trifluoroacetate salt (1-25 μM; 3 days) reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres, and blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures[1].
Carboxy pyridostatin trifluoroacetate salt (10 μM; 24 h) hinders stress granule (SG) formation in U2OS cells[3].
In Vivo:Carboxy pyridostatin trifluoroacetate salt (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice[1].
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