Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
CAS No. : 2435572-48-6
(Synonyms: Cereblon Ligand-Linker Conjugates 12; E3 Ligase Ligand-Linker Conjugates 23)
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| Cat. No. : | HY-112600 |
| M.Wt: | 534.56 |
| Formula: | C25H34N4O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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- Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
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