LDC7559


CAS No. : 2407782-01-6

2407782-01-6
Price and Availability of CAS No. : 2407782-01-6
Size Price Stock
1mg $80 In-stock
5mg $172 In-stock
10mg $275 In-stock
25mg $550 In-stock
50mg $880 In-stock
100mg $1300 In-stock
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Cat. No. : HY-111674
M.Wt: 349.38
Formula: C20H19N3O3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 2407782-01-6 :

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages [1]. IC50 & Target: Gasdermin D[1]. In Vitro: LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells[3].
LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process[3].

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