Bobcat339 (hydrochloride)
CAS No. : 2436747-44-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $320 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-111558A |
| M.Wt: | 334.20 |
| Formula: | C16H13Cl2N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].
In Vitro:Bobcat339 (10 μM; 24 hours) hydrochloride significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells[1].
Nicholas A Weirath, et al. found that the inhibitory activity of Bobcat339 is directly related to the Cu(II) content. The inhibitory activity of Bobcat339-copper mixture on TET is much higher than that of Bobcat339 or Cu(II) alone[2].
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