Bobcat339
CAS No. : 2280037-51-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $320 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-111558 |
| M.Wt: | 297.74 |
| Formula: | C16H12ClN3O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].
In Vitro:Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells[1].
Nicholas A Weirath, et al. found that the inhibitory activity of Bobcat339 is directly related to the Cu(II) content. The inhibitory activity of Bobcat339-copper mixture on TET is much higher than that of Bobcat339 or Cu(II) alone[2].
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