BI-3663
CAS No. : 2341740-84-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $610 | In-stock |
| 10mg | $980 | In-stock |
| 25mg | $2050 | In-stock |
| 50mg | $3300 | In-stock |
| 100mg | $5350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-111546 |
| M.Wt: | 917.84 |
| Formula: | C44H42F3N7O12 |
| Purity: | >98 % |
| Solubility: | DMSO : 300 mg/mL (ultrasonic) |
BI-3663 is a highly selective PTK2/FAK PROTAC (DC50 = 30 nM) with a Cereblon E3 ligase ligand capable of degrading PTK2, with an IC50 value of 18 nM. BI-3663 is a PROTAC generated by linking the PTK2/FAK inhibitor BI-4464 (HY-124625) with a Pomalidomide (HY-10984) derivative via a linker. BI-3663 can induce PTK2 degradation at low nanomolar concentrations. BI-3663 has antitumor activity[1]. IC50 & Target:IC50: 18 nM (PTK2)[1] In Vitro:BI-3663 potently degrades PTK2 in Hep3B2.1-7 cells, and A549 cells, with pDC50s of 7.6 and 7.9, respectively[1].
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