EML741
CAS No. : 2328074-38-8
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| Cat. No. : | HY-111544 |
| M.Wt: | 523.75 |
| Formula: | C31H49N5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 μM for G9a. EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated[1].
IC50 & Target: IC50: 23 nM (G9a), 3.1 μM (DNMT1)[1]
Kd: 1.13 μM (G9a)[1]
In Vitro: EML741 (Compound 12a) shows a similar high inhibition potency against G9a (97%, 98% inhibition at 10 μM and 25 μM, respectively) and GLP (95%, 98% inhibition at 10 μM and 25 μM, respectively)[1].
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- Cat. No.:
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