MGV354
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|---|---|---|
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| Cat. No. : | HY-111516 |
| M.Wt: | 575.70 |
| Formula: | C35H37N5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively[1][2]. IC50 & Target: soluble guanylate cyclase[1][2] In Vitro: MGV354 (0.1 nM-10 μM) treatment for 1 hour causes a dose-dependent increase in cGMP levels in normal human trabecular meshwork (NTM) cells (average EC50=2.5±1.6 nM) following treatment with ODQ (20 μM). The average cGMP produced by MGV354 in human NTM cells is 46±28 nM. MGV354 (1 μM) causes a linear increase in intracellular cGMP levels in a time-dependent manner (assay conditions up to 3 hours) in NTM cells[3]. In Vivo: MGV354 (Compound (+)-23) robustly lowers intraocular pressure in a cynomolgus model of elevated intraocular pressure over 24 h after a single topical ocular drop[1].
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Inquiry Information- Product Name:
- MGV354
- Cat. No.:
- HY-111516
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