GSK2643943A
CAS No. : 2449301-27-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $98 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $490 | In-stock |
| 100mg | $720 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111458 |
| M.Wt: | 277.30 |
| Formula: | C17H12FN3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) [1][2].
IC50 & Target: IC50: 160 nM (USP20/Ub-Rho)[1]
In Vitro: GSK2643943A blocks the USP20-mediated cleavage of protein-ubiquitin bonds[2].
GSK2643943A (1 μM, 5 μM; overnight) renders SCC9 cells more susceptible to oHSV-1 induced oncolysis[2].
GSK2643943A (1μM) leds to a notable increase of virus yields in SCC9 with 0.01 MOI T1012G infection[2].
In Vivo: GSK2643943A (5 mg/kg, i.p., daily, for 6 days) potentiates oHSV-1-induced oncolysis in SCC9 tumors[2].
GSK2643943A (2.5 mg/kg, i.p., daily, for 9 days) plays a regulatory role in oHSV-1 T1012G replication and oncolysis in SCC7 cells[2].
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