cGAMP (disodium)
CAS No. : 2407516-83-8
(Synonyms: Cyclic GMP-AMP (disodium); 3',3'-cGAMP (disodium))
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| 1mg | $330 | In-stock |
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| Cat. No. : | HY-110385 |
| M.Wt: | 718.37 |
| Formula: | C20H22N10Na2O13P2 |
| Purity: | >98 % |
| Solubility: | H2O : 180 mg/mL (ultrasonic;warming) |
cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
In Vitro:cGAMP disodium promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
cGAMP disodium directly activates murine and human dendritic cells in vitro[2].
On stimulation with cGAMP disodium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
cGAMP disodium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].
In Vivo:cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].
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