Cyclic-di-GMP (disodium)
CAS No. : 2222132-40-1
(Synonyms: c-di-GMP (disodium); cyclic diguanylate (disodium); 5GP-5GP (disodium))
| Size | Price | Stock |
|---|---|---|
| 1mg | $170 | In-stock |
| 5mg | $450 | In-stock |
| 10mg | $620 | In-stock |
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| Cat. No. : | HY-110382 |
| M.Wt: | 734.37 |
| Formula: | C20H22N10Na2O14P2 |
| Purity: | >98 % |
| Solubility: | H2O : 160 mg/mL (ultrasonic) |
Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research[1][2][3][4].
IC50 & Target:STING[1][2][3][4].
In Vitro:Cyclic-di-GMP disodium (0.5-50 μM; 5 days) inhibits proliferation of human colon cancer cells[1].
Cyclic-di-GMP disodium (0.5-50 μM; 5 days) specifically elevates CD4 expression in Jurkat cells[2].
Cyclic-di-GMP disodium (0.5-50 μM; 5 days) induces cell cycle arrest at the S-phase in Jurkat cells[2].
In Vivo:Cyclic-di-GMP disodium (100 μg/per; i.v.; two sequential vaccinations 9 days apart) enhances TriVax-induced immune responses to melanoma in mice and further increased the anti-tumor effects of TriVax[3].
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