BMS-599626 (dihydrochloride)
CAS No. : 1781932-33-9
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| Cat. No. : | HY-110333 |
| M.Wt: | 603.48 |
| Formula: | C27H29Cl2FN8O3 |
| Purity: | >98 % |
| Solubility: |
BMS-599626 dihydrochloride is a small molecule pan-HER (human epidermal growth factor receptor) kinase inhibitor. BMS-599626 dihydrochloride primarily targets HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activity in the HER family. BMS-599626 inhibits the kinase activity of HER1 and HER2 by competing with their ATP-binding sites, and can inhibit the downstream signaling pathway by blocking the heterodimer formation of HER1 and HER2. BMS-599626 dihydrochloride can be used to study the antitumor effects of multiple HER1 or HER2 overexpressed tumor models[1].
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- Cat. No.:
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