PKI-166 (hydrochloride)
CAS No. : 2230253-82-2
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| Cat. No. : | HY-110328 |
| M.Wt: | 366.84 |
| Formula: | C20H19ClN4O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PKI-166 hydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM[1].
IC50 & Target: IC50: 0.7 nM (EGFR tyrosine kinase)[1]
In Vitro: PKI-166 hydrochloride (0-0.5 μM; 1 hour; pretreatment) inhibits EGFR autophosphorylation in human pancreatic cancer cells[1].
PKI-166 hydrochloride (0.03 μM; 6 days) enhances the cytotoxicity mediated by gemcitabine[1].
In Vivo: PKI-166 hydrochloride (100 mg/kg; p.o.; daily; for 29 days) inhibits of pancreatic cancer growth[1].
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- PKI-166 (hydrochloride)
- Cat. No.:
- HY-110328
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