GSK840
CAS No. : 2361146-30-5
(Synonyms: GSK'840)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $435 | In-stock |
| 100mg | $650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-104021 |
| M.Wt: | 365.43 |
| Formula: | C21H23N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 110 mg/mL (ultrasonic) |
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM[1].
IC50 & Target: IC50: 0.3 nM (RIP3)[1]
In Vitro: GSK840 (GSK'840) (0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in a concentration-dependent manner[1].
GSK840 binds the kinase domain and inhibits kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli than can be achieved with RIP1 kinase inhibitors[1].
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