IACS-9571 (hydrochloride)
CAS No. : 2319611-93-1
(Synonyms: ASIS-P040 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $250 | In-stock |
| 10mg | $450 | In-stock |
| 50mg | $1650 | In-stock |
| 100mg | $2650 | In-stock |
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| Cat. No. : | HY-102000B |
| M.Wt: | 679.22 |
| Formula: | C32H43ClN4O8S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming);H2O : 10 mg/mL (ultrasonic) |
IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively[1].
IC50 & Target: IC50: 8 nM (TRIM24)[1]
Kd: 31 nM (TRIM24), 14 nM (BRPF1)[1]
In Vitro: IACS-9571 Hydrochloride shows excellent cellular potency with EC50 of 50 nM. IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24[1].
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