RG7800 (tetrahydrochloride)
(Synonyms: RO6885247 (tetrahydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-101792A |
| M.Wt: | 562.36 |
| Formula: | C24H32Cl4N6O |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 113.5 mg/mL |
RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy. IC50 & Target:EC1.5x: 23 nM (SMN2 splicing), 87 nM (SMN protein)[1] In Vitro: RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; and is the first small molecule SMN2 splicing modifier to enter human clinical trials[1]. In Vivo: RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. RG7800 (1, 3, 10 mg/kg, p.o.) dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice[1].
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Inquiry Information- Product Name:
- RG7800 (tetrahydrochloride)
- Cat. No.:
- HY-101792A
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