PI3K-IN-2
CAS No. : 1403458-28-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $575 | In-stock |
| 10mg | $957 | In-stock |
| 25mg | $2010 | In-stock |
| 50mg | $3222 | In-stock |
| 100mg | $5160 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101517 |
| M.Wt: | 525.54 |
| Formula: | C28H29F2N3O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively)[1]. IC50 & Target: IC50: 7.1, 8.6 nM (PI3Kβ/δ), 13, 190 nM (PI3Kσ/γ)[1] In Vitro: PI3K-IN-2 (compound 10) shows PI3Kβ cell IC50 1.1 nM in phosphatase and tensin homolog (PTEN) null MDA-MB-468 cell and PI3Kδ cell IC50 14 nM in Jeko-1 B-cell[1]. In Vivo: PI3K-IN-2 shows profound pharmacodynamic modulation of AKT phosphorylation in PTEN-deficient PC3 prostate tumour bearing mice after oral administration and gave significant inhibition of tumour growth in the same xenograft model[1].
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