CYP17-IN-1
CAS No. : 2093317-51-0
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|---|---|---|
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| Cat. No. : | HY-101516 |
| M.Wt: | 312.40 |
| Formula: | C18H17FN2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1]. IC50 & Target: IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1] In Vitro: CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1]. In Vivo: CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].
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