GKI-1
CAS No. : 2444764-03-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $750 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-100521 |
| M.Wt: | 269.73 |
| Formula: | C15H12ClN3 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 µM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 µM, but only weakly affected PKA[1]. IC50 & Target: IC50: 4.9 µM (hGWLFL), 4.9 µM (hGWL-KinDom)[1] In Vitro: GKI-1 inhibits full-length human GWL, and shows cellular efficacy[1].
Treatment of HeLa cells (25 and 50 µM, 0-8.5 hours) with GKI-1 reduces ENSA/ARPP19 phosphorylation levels, resulting in a decrease in mitotic events, mitotic arrest/cell death and cytokinesis failure[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- GKI-1
- Cat. No.:
- HY-100521
- Quantity:
Your information is safe with us.