SRI-011381 (hydrochloride)
CAS No. : 2070014-88-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $670 | In-stock |
| 200mg | $1325 | In-stock |
| 500mg | $2135 | In-stock |
| 1g | $2970 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-100347A |
| M.Wt: | 365.94 |
| Formula: | C20H32ClN3O |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic);H2O : 25 mg/mL (ultrasonic) |
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2]. IC50 & Target: TGF-beta[1] In Vitro: SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1]. In Vivo: SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2].
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