A-196


CAS No. : 1982372-88-2

1982372-88-2
Price and Availability of CAS No. : 1982372-88-2
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5mg $90 In-stock
10mg $120 In-stock
50mg $480 In-stock
100mg $850 In-stock
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Cat. No. : HY-100201
M.Wt: 359.25
Formula: C18H16Cl2N4
Purity: >98 %
Solubility: DMSO : 12.5 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 1982372-88-2 :

A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity[1]. IC50 & Target:IC50: 25 nM (SUV420H1) and 144 nM (SUV420H2)[1]. In Vitro:A-196 (0-5 μM; 48 hours; U2OS cells) treatment results in an increase in H4K20me1 (EC50 value of 735 nM) and a decrease in both H4K20me2 and H4K20me3 (EC50 values of 262 and 370 nM, respectively)[1].
A-196 (10 μM; 72 hours; Wild-type, Suv4-20h double knockout and inhibitortreated mouse embryonic fibroblast cells) inhibits both SUV4-20 enzymes in cells in multiple tissue types without overt toxicity[1].

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