Size | Price | Stock |
---|---|---|
5mg | $90 | In-stock |
10mg | $120 | In-stock |
50mg | $480 | In-stock |
100mg | $850 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-100201 |
M.Wt: | 359.25 |
Formula: | C18H16Cl2N4 |
Purity: | >98 % |
Solubility: | DMSO : 12.5 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity[1].
IC50 & Target:IC50: 25 nM (SUV420H1) and 144 nM (SUV420H2)[1].
In Vitro:A-196 (0-5 μM; 48 hours; U2OS cells) treatment results in an increase in H4K20me1 (EC50 value of 735 nM) and a decrease in both H4K20me2 and H4K20me3 (EC50 values of 262 and 370 nM, respectively)[1].
A-196 (10 μM; 72 hours; Wild-type, Suv4-20h double knockout and inhibitortreated mouse embryonic fibroblast cells) inhibits both SUV4-20 enzymes in cells in multiple tissue types without overt toxicity[1].
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