Rotigotine
CAS No. : 99755-59-6
(Synonyms: N-0923; (-)-N 0437)
| Size | Price | Stock |
|---|---|---|
| 100mg | $73 | In-stock |
| 250mg | $138 | In-stock |
| 1g | $372 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-75502 |
| M.Wt: | 315.47 |
| Formula: | C19H25NOS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research[1][2][3][4]. IC50 & Target:Ki: 0.71?nM (dopamine D3 receptor), 4-15?nM (D2, D5, D4 receptors), 83?nM (dopamine D1 receptor)[1][2], 176 nM (α1A), 273 nM (α1B), 338 nM (α2A), 27 nM (α2B), 30 nM (5-HT1A), 86 nM (5-HT7)[2] In Vitro: Rotigotine (0.01-10 μM) slightly protects dopaminergic neurons against MPP+ toxicity dopamine, protects dopaminergic neurons against rotenone-induced cell death and significantly inhibits ROS production by rotenone[2]. In Vivo: Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague-Dawley rats) has antidepressant effect[3].
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