ONO-RS-082
CAS No. : 99754-06-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $115 | In-stock |
| 50mg | $360 | In-stock |
| 100mg | $540 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-123070 |
| M.Wt: | 371.86 |
| Formula: | C21H22ClNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
ONO-RS-082 is an inhibitor of phospholipase A (PLA)[1]. ONO-RS-082 inhibits PLA2 with the IC50 of 1.0 μM, but does not inhibit PLC even at 100 μM[2].
In Vitro: ONO-RS-082 (10 μM) prevents P. aeruginosa strain PAO1-induced polymorphonumclear cells (PMNs) transepithelial migration, demonstrating that PLA2 activity is crucial to this process[3].
In Vivo: In vivo long-term activation of KCNK3 by ONO-RS-082 (50 mg/kg/day; preventive treatment, day 0 to day 21) reduces the development of PH in the MCT-PH model[4].
In contrast, in vivo short-term KCNK3 activation by ONO-RS-082 (curative treatment) fails to reduce PH symptoms, which is attributed to the complete loss of KCNK3 expression in MCT-PH rats at days 14 to 21[4].
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