Saccharopine
CAS No. : 997-68-2
(Synonyms: L-Saccharopine)
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| Cat. No. : | HY-W040307 |
| M.Wt: | 276.29 |
| Formula: | C11H20N2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.3 mg/mL (ultrasonic;warming) |
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3]. In Vitro: Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1]. In Vivo: Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice[1].
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