Ondansetron (hydrochloride)
CAS No. : 99614-01-4
(Synonyms: GR 38032 (hydrochloride); SN 307 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
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| 100mg | $92 | In-stock |
| 1g | $106 | In-stock |
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| Cat. No. : | HY-B0002 |
| M.Wt: | 329.82 |
| Formula: | C18H20ClN3O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Ondansetron (GR 38032; SN 307) hydrochloride is a highly selective 5-HT3 receptor antagonist with an IC50 value of 103 pM. Ondansetron hydrochloride exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron hydrochloride can inhibit nausea and vomiting induced by chemotherapy and radiotherapy[1][2][3][4][5][6][7][8].
In Vitro:Ondansetron (1-1000 μM) hydrochloride dose-dependently reduces the response of EAAT3 to 30 μM L-glutamate with an IC50 of 8.57 μM[9].
In Vivo:Ondansetron (2.4-6 mg/kg; i.p.; six times over 15 days) hydrochloride has a TD50 value of 3.7 mg/kg and an LD50 of 4.6 mg/kg[4] in mice.
Ondansetron (2 mg/kg; i.p.; six consecutive days) hydrochloride exhibits anti-inflammatory effects in rats through the 5-HT3 receptor[8].
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