K-252a
CAS No. : 99533-80-9
(Synonyms: SF2370; Antibiotic K 252a; Antibiotic SF 2370)
| Size | Price | Stock |
|---|---|---|
| 1mg | $140 | In-stock |
| 5mg | $500 | In-stock |
| 10mg | $850 | In-stock |
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| Cat. No. : | HY-N6732 |
| M.Wt: | 467.47 |
| Formula: | C27H21N3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming) |
K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene[3]. IC50 & Target: IC50: 470 nM (PKC), 140 nM (PKA), 270 nM (Ca2+/calmodulin-dependent kinase type II), 1.7 nM (phosphorylase kinase)[1][2]. In Vitro: K-252a (3-100 nM, 8d) inhibits NGF-promoted neurite outgrowth[5]. In Vivo: K252a (20 mg/kg/day) inhibiting TrkB pathway dampens the neuroprotective effects induced by TH[6].
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