Pranidipine
CAS No. : 99522-79-9
(Synonyms: OPC-13340)
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|---|---|---|
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| 10mg | $128 | In-stock |
| 25mg | $256 | In-stock |
| 50mg | $410 | In-stock |
| 100mg | $650 | In-stock |
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| Cat. No. : | HY-19664 |
| M.Wt: | 448.47 |
| Formula: | C25H24N2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 270 mg/mL (ultrasonic) |
Pranidipine (OPC-13340) is an orally active L-type voltage-dependent calcium channel (L-VDCC) blocker with a Ki value of 0.16 nM. Pranidipine inhibits calcium-induced contraction, suppresses slow-response action potentials, shortens action potential duration, reduces systolic and diastolic blood pressure, and exerts vasodilatory effects. Pranidipine enhances its vasodilatory effect by blocking NO decomposition. Pranidipine can be used in research related to essential hypertension, angina pectoris, myocardial infarction, and dilated cardiomyopathy[1][2][3].
IC50 & Target:Calcium channel[1]
In Vitro:Pranidipine (10-11-10-7 M) potently relaxes KCl-induced contractions of isolated rat thoracic aortic strips, with an ED50 of 5.9×10-10 M, exhibiting selective voltage-dependent calcium channel blocking activity[1].
Pranidipine (10-8-10-5 M) relaxes norepinephrine (HY-13715)-induced contractions of isolated rat thoracic aortic strips, with an ED50 of 8.7×10-6 M. It exhibits lower blocking potency for receptor-operated calcium channels compared with voltage-dependent calcium channels[1].
Pranidipine (3×10-6 M) shortens the action potential duration of isolated guinea pig right ventricular papillary muscles and inhibits slow-response action potentials, which is consistent with its calcium channel blocking activity[1].
Pranidipine (10-9-10-7 M; 20 min) does not alter the activity of constitutive nitric oxide synthase in cultured porcine aortic endothelial cells[2].
Pranidipine (10-6 M) enhances NO-mediated effects in an endothelial-smooth muscle cell co-culture system by inhibiting superoxide anion-induced NO decomposition, increasing cGMP accumulation, and reducing endothelin-1 production[3].
In Vivo:Pranidipine (0.3-3 mg/kg; p.o.) produces potent, long-lasting hypotensive effects with minimal tachycardia in two kidney one-clip renal hypertensive rats, with greater potency than Nicardipine (HY-12515)[1].
Pranidipine (3 mg/kg/day; chronic; 10 weeks) reduces blood pressure, urinary protein excretion, and glomerular/arteriolar sclerosis in subtotal nephrectomized spontaneously hypertensive rats[3].
Pranidipine protects the kidneys and brain from pathological damage and prolongs survival in salt-sensitive Dahl rats[3].
Pranidipine (3 mg/kg; 4 weeks) reduces cardiac pressures, prevents ventricular remodeling, and normalizes neurohormonal levels in Wistar rats with coronary artery ligation-induced myocardial infarction[3].
Pranidipine prevents brain, heart, and kidney injury and prolongs survival in stroke-prone spontaneously hypertensive rats[3].
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