BTZO-1
CAS No. : 99420-15-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $138 | In-stock |
| 25mg | $324 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $913 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-110084 |
| M.Wt: | 240.28 |
| Formula: | C13H8N2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic) |
BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1]. IC50 & Target:Kd:68.6 nM (Macrophage migration inhibitory factor)[1] In Vitro: BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5), the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM[1]. BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes[1].
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