Venlafaxine (hydrochloride)
CAS No. : 99300-78-4
(Synonyms: Wy 45030 hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $66 | In-stock |
| 50mg | $131 | In-stock |
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| Cat. No. : | HY-B0196A |
| M.Wt: | 313.86 |
| Formula: | C17H28ClNO2 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL;DMSO : 50 mg/mL (ultrasonic) |
Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].
In Vitro: Venlafaxine hydrochloride (Wy 45030 hydrochloride) dose-dependently inhibits binding of the serotonin transporter radioligand [3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a Ki of 2.48 μM. Venlafaxine hydrochloride inhibits binding of the NE transporter ligand [3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a Ki of 82 nM[1].
Venlafaxine hydrochloride inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED50 values of 2 and 54 mg/kg, respectively[1].
In Vivo: Venlafaxine hydrochloride (Wy 45030 hydrochloride; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA[1].
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