Imiquimod
CAS No. : 99011-02-6
(Synonyms: R 837)
| Size | Price | Stock |
|---|---|---|
| 100mg | $66 | In-stock |
| 200mg | $86 | In-stock |
| 500mg | $151 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-B0180 |
| M.Wt: | 240.30 |
| Formula: | C14H16N4 |
| Purity: | >98 % |
| Solubility: | H2O : 2.64 mg/mL (ultrasonic;adjust pH to 2 with HCl);DMSO : 3.28 mg/mL (ultrasonic;warming;adjust pH to 7 with 1 M HCl;heat to 60°C);Methanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C) |
Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].
IC50 & Target:toll-like receptor 7[1]
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Imiquimod (IMQ) can be used to induce psoriasis models[5].
Administration: 3.125 mg/day • skin • 6 days
(1) Prepare BM of lipids
STA and OA were melted at 75 °C followed by the addition of IMQ (3.5% of the BM, w/w) under continuous stirring.
Polysorbate 80 and stearoyl polyoxyl-32 glycerides at a 50:50 ratio were dispersed in water heated separately to 75 °C and added to the BM phase under continuous stirring.
(2) Prepare nanostructured lipid carriers (NLCs)
The mixture was then subjected to high-shear homogenization followed by ultrasonication.
The mixture was then rapidly cooled in an ice bath to allow the formation of NLCs.
Resulted in hyperproliferative keratinocytes and a disturbed epidermal differentiation (parakeratosis).
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