Pyrazoloacridine
CAS No. : 99009-20-8
(Synonyms: NSC 366140; PD 115934)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $600 | In-stock |
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| Cat. No. : | HY-108969 |
| M.Wt: | 367.40 |
| Formula: | C19H21N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment[1][2].
In Vitro: Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC50 values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells[1].
Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro[2].
Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer[2].
Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells[2].
Pyrazoloacridine (NSC 366140) induces apoptosis in P53-deficient Hep 3B human hepatoma cells[2].
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