Methyl paraben
CAS No. : 99-76-3
(Synonyms: Methyl 4-hydroxybenzoate)
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|---|---|---|
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| 1000g | $53 | In-stock |
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| Cat. No. : | HY-N0349 |
| M.Wt: | 152.15 |
| Formula: | C8H8O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Methyl Paraben is a standardized methyl paraben allergen isolated from Yunnan hemlock (Tsuga dumosa). Methyl Paraben is commonly used as a stable, non-volatile preservative. Methyl Paraben increases histamine release and cellular regulation of immunity, blocks sodium channels, and prevents ischemia-reperfusion injury[1][2][3][4].
In Vitro: Methyl paraben (0-1 μM; 48 h) reduces basal lipolysis of mature 3T3-L1 white fat cells, such as insulin-stimulated glucose uptake. But does not change the base 2-NBDG uptake[2].
Methyl paraben (100 μg/mL; 48-72 h) significantly inhibits follicle growth in mice[3].
In Vivo: Methyl paraben (1, 10 and 50 mg/kg; ip; single dose, 30 min before 6-OHDA) prevents rotation behavior induced by Apomorphine (HY-12723) and significantly improves motor deficits in 6-OHDA (HY-B1081) -injured mice[4].
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