Valproic acid
CAS No. : 99-66-1
(Synonyms: VPA; 2-Propylpentanoic acid; Dipropylacetic acid)
| Size | Price | Stock |
|---|---|---|
| 25g | $14 | In-stock |
| 100g | $50 | In-stock |
| 500g | $137 | In-stock |
| 1000g | $273 | In-stock |
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| Cat. No. : | HY-10585 |
| M.Wt: | 144.21 |
| Formula: | C8H16O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 2.5 mg/mL (ultrasonic;warming;heat to 60°C);0.1 M NaOH : 50 mg/mL (ultrasonic) |
Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[1][2][3][4][5][6][7].
IC50 & Target:IC50: 400 μM (HDAC1), 0.5-2 mM (HDAC)[5]
HDAC2[6]
In Vitro:Valproic acid (VPA) (0-15 mM; 24 and 72 h) inhibits Hela cell growth in a dose- and time- dependent manner[1].
Valproic acid (10 mM; 24 h) significantly attenuates the activities of total, cytosol and nuclear HDACs[1].
Valproic acid (0-15 mM; 24 h) induces a G1 phase arrest at 1–3 mM and a G2/M phase arrest at 10 mM, and increases the percentage of sub-G1 cells in HeLa cells. Valproic acid also induces necrosis, apoptosis and lactate dehydrogenase (LDH) release[1].
Valproic acid (0-20 mM; 24 h) activates Tcf/Lef-dependent transcription and synergizes with lithium[2].
Valproic acid (0-5 mM; 0-18 h) increases β-catenin levels in Neuro2A cells[2].
Valproic acid (0-2 mM; 0-24 h) stimulates phosphorylation of AMPK and ACC in hepatocytes[5].
Valproic acid (0-10 mM; 2 days) induces Notch1 signaling and morphologic differentiation, suppresses production of NE tumor markers in SCLC cells[6].
In Vivo:Valproic acid (VPA) (500 mg/kg; i.p.; daily for 12 days) inhibits tumor angiogenesis in mice transplanted with Kasumi-1 cells[3].
Valproic acid (350 mg/kg; i.p.; once) enhances social behavior in rats[4].
Valproic acid (0.26% (w/v); p.o. via drinking water; 14 days) decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice without hepatotoxicity[5].
The solution of this product, when dissolved in Saline, is acidic. Before administration to animals, the pH must be adjusted to neutral (pH=7) with sodium hydroxide (e.g., 1M NaOH).
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