Prunasin
CAS No. : 99-18-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $175 | In-stock |
| 5mg | $650 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-N1548 |
| M.Wt: | 295.29 |
| Formula: | C14H17NO6 |
| Purity: | >98 % |
| Solubility: |
Prunasin is an orally active cyanogenic glucoside and the main metabolite of Amygdalin (HY-N0190). Prunasin can specifically inhibit rat DNA polymerase β (IC50: 98 μM). Prunasin has anti-inflammatory and anti-fibrotic activities. Prunasin can be used in the research of diseases such as liver fibrosis[1][2].
In Vitro:Prunasin (6.25-100 μM; 22 h) can inhibit the production of NO in RAW264.7 cells and suppress the expression of α-SMA and Col1A1 in JS1 cells[2].
In Vivo:Prunasin (1.25-5 mg/kg; oral administration; 3 weeks) exerts an ameliorative effect in a mouse model of liver fibrosis[2].
Pharmacokinetic Analysis in Rats[2]
| Route and Dose (mg/kg) | ke (/min) | T1/2ke (min) | Cmax (ng/mL) | Tmax (min) | AUC0-t (ng•min/mL) | AUC0-∞ (ng•min/mL) | MRT (min) | Vd (mL/kg) | CL (mL/min/kg) | F (%) |
| i.v. 5 | 0.010 | 69.42 | 6926.50 | 2.00 | 207670.12 | 208663.12 | 43.94 | 2469.24 | 25.05 | / |
| p.o. 5 | 0.013 | 63.48 | 2912.06 | 16.00 | 134797.34 | 135731.78 | 46.80 | 3369.66 | 37.02 | 64.91 |