3,5-Dihydroxybenzoic acid
CAS No. : 99-10-5
| Size | Price | Stock |
|---|---|---|
| 25g | $11 | In-stock |
| 100g | $16 | In-stock |
| 500g | $54 | In-stock |
| 1000g | $100 | In-stock |
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| Cat. No. : | HY-W015560 |
| M.Wt: | 154.12 |
| Formula: | C7H6O4 |
| Purity: | >98 % |
| Solubility: | H2O : 60 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses. 3,5-Dihydroxybenzoic acid is the agonist for hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) that inhibits lipolysis in adipocytes. 3,5-Dihydroxybenzoic acid is the competitive inhibitor for tyrosine phenol-lyase (TPL), exhibits an affinity of Ki=25.7 μM. 3,5-Dihydroxybenzoic acid is orally active[1][2].
In Vitro:3,5-Dihydroxybenzoic acid couples with Gi/o protein, inhibits the cAMP accumulation in HCA1 expressing SK-N-MC cell with an IC50 of 112 μM[1].
3,5-Dihydroxybenzoic acid inhibits tyrosine phenol-lyase (TPL), blocks the conversion of L-tyrosine to phenol in bacteria Citrobacter koseri and Morganella morganii, without affecting the bacterial growth[2].
In Vivo:3,5-Dihydroxybenzoic acid (0.2% added to feed, po for 2 days) reduces fecal phenol levels in mice fed a high-tyrosine diet, exhibits potential application in research of uremic symptoms associated with phenol toxicity[2].
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