ATP disodium salt, 100mM Solution, PCR Grade

ATP (Adenosine 5'-triphosphate) disodium salt, 100mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice^[1][2][3][4]. In Vitro:ATP (5 mM; 1 hour) disodium salt, 100mM Solution, PCR Grade co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3].
ATP (2 mM; 0.5-24 hours) disodium salt, 100mM Solution, PCR Grade induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner^[4].
ATP disodium salt, 100mM Solution, PCR Grade promotes neutrophil chemotaxis^[4].
In Vivo:ATP (50 mg/kg; i.p., 1-24 h before bacterial challenge) disodium salt, 100mM Solution, PCR Grade protects mice against bacterial infection in mice, such as E. coli and S. aureus^[4].