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ATP (disodium salt)


CAS No. : 987-65-5

(Synonyms: Adenosine 5'-triphosphate (disodium salt); Disodium adenosine triphosphate)

987-65-5
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Cat. No. : HY-B0345A
M.Wt: 551.14
Formula: C10H14N5Na2O13P3
Purity: >98 %
Solubility: DMSO : < 1 mg/mL;H2O : 100 mg/mL (ultrasonic)
Introduction of 987-65-5 :

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation[1][2]. In Vitro: ATP disodium salt (5 mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4].
ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4].
In Vivo: ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

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