| Size | Price | Stock |
|---|---|---|
| 5mg | $175 | In-stock |
| 10mg | $240 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-N2245 |
| M.Wt: | 356.41 |
| Formula: | C21H24O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera[1]. Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia[2].
In Vitro:Schisandrone (4-32 µg/mL) inhibits Hla hemolytic activity without affecting the growth of S. aureus[2].
Schisandrone (4-32 µg/mL) has no apparent cytotoxicity and prevents S. aureus‑mediated A549 cell injury[2].
In Vivo:Schisandrone (40 mg/kg, s.c.) combined with antibiotic Ceftiofur exhibits a significant therapeutic effect on S. aureus infection in mice[2].
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