Ethaverine (hydrochloride)
CAS No. : 985-13-7
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| Cat. No. : | HY-B1440 |
| M.Wt: | 431.95 |
| Formula: | C24H30ClNO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3].
In Vitro: Ethaverine hydrochloride (10 μM, PC12 cells) reduces catecholamine secretion by blocking the L-type voltage-sensitive Ca2+ channel[2].
Ethaverine hydrochloride (12 h) decreases dopamine content by inhibiting tyrosine hydroxylase (TH) activity in PC12 cells, with an IC50 of 1.4 μM[3].
Ethaverine hydrochloride inhibits monoamine oxidase (MAO) activity in mouse brain (isolated from mouse whole brain), with an IC50 of 25.5 μM[6].
In Vivo: Ethaverine hydrochloride (2-10 mg/kg, intravenous infusion, i.v.) causes significant elevation of endocochlear potential in guinea pigs[4].
Ethaverine (1-10 mg/kg, i.v.) inhibits atrioventricular conduction and heart rate in the anaesthetized dog[5].
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